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  • Title: miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression.
    Author: Gao Y, Luo LH, Li S, Yang C.
    Journal: Biochem Biophys Res Commun; 2014 Feb 07; 444(2):230-4. PubMed ID: 24462867.
    Abstract:
    MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3'-untranslated region (3'-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.
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