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  • Title: [Pro-apoptosis and selective anticancer activities of prostate apoptosis response protein 4: research progress and prospects].
    Author: Wu Z, Wang G, Zhang K.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2014 Jan; 34(1):128-32. PubMed ID: 24463134.
    Abstract:
    As a pro-apoptotic factor, prostate apoptosis response protein 4 (par-4) was first found in the male hormone-dependent prostate cells (AT-3). Endogenous Par-4 sensitizes cancer cells to apoptotic stimuli, but exogenous Par-4 selectively induces apoptosis in cancer cells, and these activities depends on the structure of its core domain SAC. Par-4 and SAC can specifically induce apoptosis of cancer cells but not of normal cells, and are therefore potential anti-cancer drugs. In this review we summarize the discovery, structure, and function of par-4, and its intracellular signaling pathways, then discuss the application prospects of Par-4 and SAC in the clinical treatment of cancer and the problems in its research and clinical applications.
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