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  • Title: [Activity of lysosomal proteolytic enzymes in rat gastric mucosa during contrical administration].
    Author: Dzodzuashvili VU.
    Journal: Vopr Med Khim; 1987; 33(5):84-5. PubMed ID: 2446426.
    Abstract:
    Contrical was shown to decrease distinctly the activity of cathepsins A, B, C and D in rat gastric mucosa in situ and in vitro. At the same time, application of contrical as a polymeric complex with glue MK-8 resulted in penetration of the drug into the incubation mixture and led to inhibition of lysosomal proteinases. The data obtained suggest that simultaneous use of contrical and glue MK-8 may serve as an adequate therapeutic approach in local treatment of gastroduodenal ulcers.
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