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  • Title: Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro.
    Author: Kulesz-Martin MF, Penetrante R, East CJ.
    Journal: Carcinogenesis; 1988 Jan; 9(1):171-4. PubMed ID: 2446796.
    Abstract:
    Stable pre-tumorigenic, benign tumor and squamous cell carcinoma stages have been isolated after treatment of a cloned mouse keratinocyte line with 7,12-dimethylbenz[a]anthracene. Intraperitoneal injection and skin grafting of athymic nude mice were suitable for growth of these well-differentiated tumor cells, whereas subcutaneous injection was not.
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