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  • Title: Repetitive paired-pulse transcranial magnetic stimulation over the visual cortex selectively inhibits focal flash VEPs.
    Author: Kimura T, Ogata K, Nakazono H, Tobimatsu S.
    Journal: Brain Stimul; 2014; 7(2):275-80. PubMed ID: 24468091.
    Abstract:
    BACKGROUND: The human visual system processes different aspects of visual information such as luminance and contrast via multiple channels. We previously used repetitive paired-pulse stimulation (rPPS) over the visual cortex to elicit a disinhibitory effect on the visual recovery function of paired pattern-reversal (PR) visual evoked potentials (VEPs). OBJECTIVE: We tested the hypothesis that different visual channels exhibit diverse response patterns after rPPS over the visual cortex. Thus, we examined how rPPS influenced each channel of the visual cortex. METHODS: We employed rPPS with a 1.5-ms interstimulus interval over the visual cortex at the stimulus intensity of the visual masking effect. Focal flash (FF) and PR-VEPs (check size, 15 min) were recorded to evaluate the response properties of visual channels in 10 healthy subjects. Visual stimuli were presented for the lower half-field that subtended 6° in radius. The amplitudes and latencies of each VEP were compared before and after rPPS for up to 30 min. RESULTS: Following rPPS, N1-P1 and P1-N2 amplitudes of FF-VEPs decreased linearly up to 30 min. In contrast, the amplitudes of PR-VEPs were not significantly changed. Latencies of FF- and PR-VEPs were also unchanged. CONCLUSIONS: Modulation of FF-VEPs by rPPS suggests that rPPS selectively induced an inhibitory effect on the luminance channel. Therefore, rPPS may be a promising tool for exploring plastic changes in the visual cortex.
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