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  • Title: Preservation of resuspended red cell concentrates. Rate of vesiculation and of spontaneous hemolysis.
    Author: Stibenz D.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1987; 114(4):469-70. PubMed ID: 2446976.
    Abstract:
    In resuspended red cell concentrates addition of sucrose, mannitol and sorbitol (30 mM final concentration each) to the SAG medium (150 mM NaCl, 50 mM glucose, 1.25 mM adenine) results in a significant reduction of the spontaneous hemolysis of the cells to about 25% after 3 weeks and to about 40% after 6 weeks preservation. Furthermore, in comparison to the SAG medium the vesiculation rate is reduced to about 40% after 3 weeks preservation. Clear cut differences in the effects between the three additives could not be found. The addition of guanosine (1.25 mM final concentration) to the SAG-sucrose or SAG-sorbitol medium has no significant effects on hemolysis and vesiculation.
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