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  • Title: Morphometrical studies of erythrophagocytosis in the spleen.
    Author: Zimmermann N, Schloeffel G, Unger J, Halbhuber KJ, Paetzold L, Linss W.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1987; 114(4):472-3. PubMed ID: 2446978.
    Abstract:
    The elimination of altered RBC was investigated morphometrically in the rat spleen by determination of the percentage of erythrophagosomes in macrophages. PHZ and diamide treated RBC led to a time dependent increase of the percentage of erythrophagosomes in comparison to normal spleens. The deformability of the target RBC was lowered as revealed by measurements with glass micropipettes. RBC-microvesicles and diamide treated RBC are primarily loaded with IgG and undergo a rapid elimination. PHZ-RBC and cells with a prolonged stay in the spleen are sequestrated by secondary mechanisms. Details of primary and secondary elimination are discussed.
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