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  • Title: The role of Ca2+-dependent biochemical changes in the ageing process in normal red cells and in the development of irreversibly sickled cells.
    Author: Allan D, Raval PJ.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1987; 114(4):499-503. PubMed ID: 2446988.
    Abstract:
    During the ageing process of normal red cells and in the formation of irreversibly sickled cells (ISCs) there is a progressive increase in the intracellular concentration of Ca2+. This is parallelled by the development of a variety of morphological and biochemical changes in older fractions of normal cells and in ISCs which are similar to those seen in normal cells exposed to Ca2+ ionophore. These changes include cell shrinkage, loss of membrane lipid and degradation of cytoskeletal proteins and polyphosphoinositides. In this paper we consider the ways in which the Ca2+-dependent biochemical changes may be related to the morphological alterations which are characteristic of ageing and irreversible sickling.
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