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  • Title: The cellular src gene product regulates junctional cell-to-cell communication.
    Author: Azarnia R, Reddy S, Kmiecik TE, Shalloway D, Loewenstein WR.
    Journal: Science; 1988 Jan 22; 239(4838):398-401. PubMed ID: 2447651.
    Abstract:
    Overexpression of the cellular src gene in NIH 3T3 cells causes reduction of cell-to-cell transmission of molecules in the 400- to 700-dalton range. This down-regulation of gap junctional communication correlates with the activity of the gene product, the protein tyrosine kinase pp60c-src. The down-regulation was enhanced by point mutation of Tyr527 (a site that is phosphorylated in pp60c-src and that inhibits kinase activity) or by substitution of the viral-src for the cellular-src carboxyl-terminal coding region. Mutation of Tyr416 (a site phosphorylated upon Tyr527 mutation) suppresses both the down-regulation of communication by Tyr527 mutation and that by gene overexpression. The regulation of communication by src may be important in the control of embryonic development and cellular growth.
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