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  • Title: Interaction of steady-state procainamide with H2-receptor antagonists cimetidine and ranitidine.
    Author: Rodvold KA, Paloucek FP, Jung D, Gallastegui J.
    Journal: Ther Drug Monit; 1987 Dec; 9(4):378-83. PubMed ID: 2447687.
    Abstract:
    This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine, on steady-state procainamide pharmacokinetics. Six healthy men were given 500 mg sustained-release procainamide every 6 h, for a total of 13 doses, on three occasions. Subjects were randomly assigned to three treatments by a Latin-square design: cimetidine 1,200 mg/day, ranitidine 300 mg/day, and no H2-receptor antagonist (control) for 4 days. Cimetidine significantly increased the procainamide area under the serum concentration-time curve by 43%, decreased renal clearance by 36%, and decreased the ratio of systemic clearance of procainamide to bioavailability by 28%. Ranitidine did not significantly alter procainamide steady-state pharmacokinetics.
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