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  • Title: [Effect of Iloprost (ZK 36 374) on hemodynamic parameters during kidney donor conditioning in animal experiments].
    Author: Rebmann U, Langkopf B, Pauer HD, Schabel J, Heynemann H, Förster W.
    Journal: Z Exp Chir Transplant Kunstliche Organe; 1987; 20(5):264-8. PubMed ID: 2447706.
    Abstract:
    Hemodynamic parameters during the conditioning of kidney donors were tested under the influence of Iloprost (ZK 36 374), a stable prostacyclin derivate, in 12 house swine of a body weight of 20-50 kg. The electromagnetically measured blood flow in the right renal artery increased on an average of 73.2% after intraaortic infusion of Iloprost (1 micrograms/kg.min) during 15 minutes. The mean arterial blood pressure decreased simultaneously by 14.7%. The renal flow resistance (RVR), by blood pressure and blood flow calculated, decreased by 49.7% in average. Iloprost appears well-suitable for conditioning donors, it shows advantages in contrast to the hitherto used drugs.
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