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  • Title: [Trauma-induced coagulopathy].
    Author: Hanke AA, Rahe-Meyer N.
    Journal: Unfallchirurg; 2014 Feb; 117(2):95-8. PubMed ID: 24477803.
    Abstract:
    The main cause of death in the patient group less than 45 years is trauma. Beside severe traumatic brain injury, bleeding remains a leading cause of death in this group. For a causal therapy, it is necessary to understand the pathophysiology of trauma-induced coagulopathy (TIC). Beside the well-known lethal triad of trauma (hypothermia, acidosis, and coagulopathy), dilution and hypoperfusion with activation of the protein C pathway play a crucial role. TIC is a complex independent syndrome which may be present without initial hypercoagulopathy. A rapid and differentiated diagnosis and goal-directed therapy is crucial for causal therapy.
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