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Title: Diagnosis of prosthetic joint infection by use of PCR-electrospray ionization mass spectrometry. Author: Greenwood-Quaintance KE, Uhl JR, Hanssen AD, Sampath R, Mandrekar JN, Patel R. Journal: J Clin Microbiol; 2014 Feb; 52(2):642-9. PubMed ID: 24478503. Abstract: We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee (n = 270) or hip (n = 161) prostheses. Of these, 152 and 279 subjects had prosthetic joint infection (PJI) and aseptic failure, respectively. The sensitivities for detecting PJI were 77.6% for PCR-ESI/MS and 69.7% for culture (P = 0.0105). The specificities were 93.5 and 99.3%, respectively (P = 0.0002).[Abstract] [Full Text] [Related] [New Search]