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  • Title: Composite gastric carcinoma. Report of a tumor of the carcinoma-carcinoid spectrum.
    Author: Ulich TR, Kollin M, Lewin KJ.
    Journal: Arch Pathol Lab Med; 1988 Jan; 112(1):91-3. PubMed ID: 2447855.
    Abstract:
    A composite tumor of the gastric antrum composed of areas of adenocarcinoma and poorly differentiated carcinoid is described, with histochemical and immunohistochemical documentation of endocrine and nonendocrine differentiation. The neoplasm maintained a composite architecture both within the site of origin and in lymph node metastases. The adenocarcinoma displayed a predominantly tubular architecture with focal sheets of clear cells. The poorly differentiated carcinoid was argyrophilic, chromogranin immunoreactive, and focally serotonin immunoreactive, and contained keratin intermediate filaments in a distinctive distribution suggestive of endocrine differentiation. Among the tumors of the carcinoma-carcinoid spectrum, the composite tumor is less common than either carcinomas with interspersed endocrine cells or carcinoids with interspersed nonendocrine cells.
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