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  • Title: 9-Amino-1,2,3,4-tetrahydroacridine (THA) is a potent blocker of cardiac potassium channels.
    Author: Osterrieder W.
    Journal: Br J Pharmacol; 1987 Nov; 92(3):521-5. PubMed ID: 2447986.
    Abstract:
    1. 9-Amino-1,2,3,4-tetrahydroacridine (THA) is a compound with structural similarity to the K+ channel blocker 4-aminopyridine. It was investigated for its effects on myocardial membrane currents in guinea-pig isolated ventricular myocytes. 2. THA prolonged the transmembrane action potential and decreased the amplitude of its plateau in a reversible manner. 3. Voltage-clamp experiments showed that THA reduced the inwardly rectifying and the time-dependent outward K+ currents as well as the slow inward Ca2+ current. 4. The degree of block of the inwardly rectifying K+ current depended on the membrane potential, being more pronounced at more positive potentials.
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