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  • Title: Construction of a detailed molecular map of the mouse X chromosome by microcloning and interspecific crosses.
    Author: Brockdorff N, Fisher EM, Cavanna JS, Lyon MF, Brown SD.
    Journal: EMBO J; 1987 Nov; 6(11):3291-7. PubMed ID: 2448136.
    Abstract:
    A large number of microclones obtained by microdissection of the mouse X chromosome have been mapped using an interspecific Mus domesticus/Mus spretus cross. Clones displaying close linkage to a number of loci of known phenotype but unknown gene product, such as mdx (X-linked muscular dystrophy), have been obtained. Over a central 30 cM span of the mouse X chromosome, 17 clones have been mapped and ordered at a sufficient density to contemplate the complete physical mapping of this region that will aid in the isolation of a number of unidentified genes. Some of the mapped microclones detect moderately repetitive sequences that were clustered in several discrete regions of the mouse X chromosome.
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