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Title: [Mechanism of postextrasystolic potentiation of the myocardium]. Author: Markhasin VS, Tsyv'ian PB, Artem'eva OG, Mil'shteĭn GN, Solov'eva OE. Journal: Fiziol Zh SSSR Im I M Sechenova; 1987 Oct; 73(10):1339-44. PubMed ID: 2448171. Abstract: Combined effects of poststimulation and postextrasystolic potentiation (PESP) were studied in the rat papillary muscles. The constant PESP augmentation of isometric force triggered by extrasystolic stimulus was shown for 2-8 poststimulatory potentiated contractions. The PESP was not dependent upon the Ca2+ concentration within the 0.5-1.2 mM range. The findings corroborate the postulate that the PESP in cardiomyocytes is associated with special Ca2+ store which is triggered by two APs: regular and extrasystolic ones.[Abstract] [Full Text] [Related] [New Search]