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  • Title: Peanut agglutinin inhibits proliferation of cultured breast cancer cells.
    Author: Marth C, Daxenbichler G.
    Journal: Oncology; 1988; 45(1):47-50. PubMed ID: 2448718.
    Abstract:
    Cultured breast cancer cells express on their surface glycoproteins which are recognized by the peanut lectin (PNA). The proliferation of these cells (ZR-75.1 and 734-B) was inhibited by PNA. A mammary carcinoma cell line (BT-20) which does not react with PNA was not affected by this lectin. The combination of PNA with either retinoic acid or 4-hydroxy-tamoxifen led to an additive amplification of the antiproliferative activity. Also interferon-gamma showed in combination with PNA an improved growth-inhibitory action.
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