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  • Title: UV sensitivity of human keratinocyte and Langerhans cell-expressed HLA-DR antigens: a comparison.
    Author: Koulu L, Jansén CT.
    Journal: Photodermatol; 1987 Aug; 4(4):176-81. PubMed ID: 2448759.
    Abstract:
    HLA-DR expression on human keratinocytes (KC) was induced in vivo by intradermal injection of purified protein derivative of tuberculin (PPD). Neither preceding nor subsequent exposure of the PPD injection site to a dose of approximately 2 MED of UVB radiation abolished KC HLA-DR, though subsequent irradiation caused a slight diminution in the intensity of the antigen expression. By contrast, epidermal Langerhans cell (LC) HLA-DR and T6 expressions in normal epidermis were greatly reduced by an identical dose of UVB. Pemphigus antigen on the surface of KC was not affected by irradiation or PPD injection.
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