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  • Title: Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature.
    Author: Internullo M, Giannelli V, Sardo L, Antonaglia C, Villani T, Angelici E, Palange P.
    Journal: Eur Rev Med Pharmacol Sci; 2014; 18(2):190-3. PubMed ID: 24488907.
    Abstract:
    Hydroxyurea is a cytotoxic agent widely used in the treatment of myeloproliferative disorders. It is considered a-well-tolerated antineoplastic drug, with a dose-related bone marrow suppression as main adverse effect. This report describes a patient with essential thrombocythemia who developed an interstitial pneumonitis and respiratory failure within 4 years from beginning therapy with hydroxyurea (HU). After discontinuing of HU. both clinical and radiological resolution of pneumonitis occurred. In conclusion, HU-induced pulmonary toxicity is a potentially life-threatening side effect.
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