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  • Title: Metal-free oxidative amidation of 2-oxoaldehydes: a facile access to α-ketoamides.
    Author: Mupparapu N, Khan S, Battula S, Kushwaha M, Gupta AP, Ahmed QN, Vishwakarma RA.
    Journal: Org Lett; 2014 Feb 21; 16(4):1152-5. PubMed ID: 24490591.
    Abstract:
    A novel and efficient method for the synthesis of α-ketoamides, employing a dimethyl sulfoxide (DMSO)-promoted oxidative amidation reaction between 2-oxoaldehydes and amines under metal-free conditions is presented. Furthermore, mechanistic studies supported an iminium ion-based intermediate as a central feature of reaction wherein C1-oxygen atom of α-ketoamides is finally derived from DMSO.
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