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  • Title: Islet cell tumors metastatic to the liver: effective palliation by sequential hepatic artery embolization.
    Author: Ajani JA, Carrasco CH, Charnsangavej C, Samaan NA, Levin B, Wallace S.
    Journal: Ann Intern Med; 1988 Mar; 108(3):340-4. PubMed ID: 2449109.
    Abstract:
    The value of sequential percutaneous hepatic artery embolization with polyvinyl alcohol particles was examined in 22 patients with islet cell carcinoma metastatic to the liver. Nine patients had gastrinoma, 2 had glucagonoma, and 11 had no discernible hormonal secretions or syndromes. Ninety-seven embolizations were done with a median number of 4 (range, 1 to 12) per patient. The interval between embolizations ranged from 1 to 8 months. Twelve of twenty evaluable patients had a partial remission, frequently associated with subjective improvement and decrease in hormone levels. The projected median survival of all 22 patients from the initiation of embolization is 33.7 months (range, 1 to 72). Nausea, vomiting, fever, and abdominal pain occurred with each embolization and subsided usually by day 10 (range, 3 to 35). Sequential hepatic artery occlusion is an effective method for prolonged palliation in this selected group of patients.
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