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  • Title: Brain stem hemorrhage due to cerebral amyloid angiopathy: the autopsy of a patient with Alzheimer's disease at a young age.
    Author: Ohtani S, Shimizu K, Asari M, Maseda C, Oka K, Yamada H, Hoshina C, Doi H, Yajima D, Shiono H, Ogawa K.
    Journal: Leg Med (Tokyo); 2014 Mar; 16(2):98-101. PubMed ID: 24491518.
    Abstract:
    We report findings from an autopsy of a male in his 40s who died of a brain stem hemorrhage associated with cerebral amyloid angiopathy (CAA), senile plaques (SPs) and neurofibrillary tangles (NFTs), which are histopathological changes associated with Alzheimer's disease (AD). Our immunohistochemical study demonstrated amyloid β (Aβ) deposition in the small cerebral arteries and SPs. Although hypertension (178/132 mmHg) was detected, the subject was not treated accordingly. CAA coupled with hypertension might have caused the intracerebral hemorrhage (ICH).
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