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  • Title: Purified L-type calcium channels: only one single polypeptide (alpha 1-subunit) carries the drug receptor domains and is regulated by protein kinases.
    Author: Glossmann H, Striessnig J, Hymel L, Schindler H.
    Journal: Biomed Biochim Acta; 1987; 46(8-9):S351-6. PubMed ID: 2449181.
    Abstract:
    The L-type calcium channel was purified from guinea-pig skeletal muscle T-tubule membranes. The purified preparation retained the binding activity for 1,4 dihydropyridines, phenylalkylamines and d-cis diltiazem. Four polypeptides with apparent molecular masses of 180-190, 150-155, 55-60 and 28-35 kDa (termed alpha 1, alpha 2, beta and gamma subunit) copurified with reversible drug binding. In photoaffinity labeling experiments only the alpha 1 subunit was shown to carry the drug receptors. Phosphorylation and functional reconstitution experiments revealed that the cAMP dependent phosphorylation of the alpha 1 subunit is responsible for calcium channel regulation.
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