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  • Title: Irreversible damage to sarcolemmal Ca2+ transport in myocardial ischemia.
    Author: Dhalla NS, Dixon IM, Beamish RE.
    Journal: Biomed Biochim Acta; 1987; 46(8-9):S505-11. PubMed ID: 2449189.
    Abstract:
    Perfusion of isolated rat hearts for 10 min with substrate-free hypoxic medium resulted in a depression of sarcolemmal Na+-dependent Ca2+ uptake, Ca2+-stimulated ATPase, ATP-dependent Ca2+ uptake and Na+-K+ ATPase in sarcolemma. Reoxygenation of these hearts resulted in a further depression of all these activities. Na+-induced Ca2+-efflux was unaffected in vesicles of hearts subjected to hypoxia-reoxygenation. Developed contractile force and resting tension in hypoxic hearts were 15% and 400% of control values, respectively, while reoxygenation was associated with a slight recovery of developed contractile force and the resting tension was lowered appreciably but remained elevated. Because sarcoplasmic reticular Ca2+ uptake and mitochondrial Ca2+ uptake were depressed under similar conditions, cellular injury due to hypoxia-reoxygenation was not specific to the sarcolemma. These results indicate that inability of the ischemic heart to recover its function may be associated with defects in Ca2+-transport systems.
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