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  • Title: Effect of protein kinase C activation on mast cell histamine release.
    Author: Palacios C, Pintado E.
    Journal: Biochem Int; 1987 Aug; 15(2):441-7. PubMed ID: 2449212.
    Abstract:
    The role of protein Kinase C activators in the process of histamine secretion has been studied in rat peritoneal mast cells purified by a density gradient. TPA (12-O-tetradecanoyl-phorbol-13-acetate), a tumor promoter which activates protein kinase C, induced histamine release in the presence and in the absence of external free Ca2+. TPA and the calcium ionophore A23187 have an additive effect on secretion. Histamine release induced by TPA is energy-dependent. In the presence of 100 microM KCN secretion was moderately inhibited, however when glucose was removed from the incubation medium TPA-induced histamine release in the presence of KCN was strongly depressed.
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