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  • Title: MiR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151.
    Author: Wang X, Yu H, Lu X, Zhang P, Wang M, Hu Y.
    Journal: Biochem Biophys Res Commun; 2014 Feb 28; 445(1):175-9. PubMed ID: 24495805.
    Abstract:
    Gastric cancer (GC) is the second common cause of cancer-related death worldwide. microRNAs (miRNAs) play important roles in the carcinogenesis of GC. Here, we found that miR-22 was significantly decreased in GC tissue samples and cell lines. Ectopic overexpression of miR-22 remarkably suppressed cell proliferation and colony formation of GC cells. Moreover, overexpression of miR-22 significantly suppressed migration and invasion of GC cells. CD151 was found to be a target of miR-22. Furthermore, overexpression of CD151 significantly attenuated the tumor suppressive effect of miR-22. Taken together, miR-22 might suppress GC cells growth and motility partially by inhibiting CD151.
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