These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: OAT3-mediated extrusion of the 99mTc-ECD metabolite in the mouse brain.
    Author: Kikuchi T, Okamura T, Wakizaka H, Okada M, Odaka K, Yui J, Tsuji AB, Fukumura T, Zhang MR.
    Journal: J Cereb Blood Flow Metab; 2014 Apr; 34(4):585-8. PubMed ID: 24496177.
    Abstract:
    After administration of the (99m)Tc complex with N,N'-1,2-ethylenediylbis-L-cysteine diethyl ester ((99m)Tc-ECD), a brain perfusion imaging agent, the radioactive metabolite is trapped in primate brain, but not in mouse and rat. Here, we investigate the involvement of metabolite extrusion by organic anion transporter 3 (OAT3), which is highly expressed at the blood-brain barrier in mice, in this species difference. The efflux rate of radioactivity in the cerebrum of Oat3(-/-) mice at later phase was 20% of that of control mice. Thus, organic anion transporters in mouse brain would be involved in the low brain retention of radioactivity after (99m)Tc-ECD administration.
    [Abstract] [Full Text] [Related] [New Search]