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  • Title: Pauson-Khand reaction of internal dissymmetric trifluoromethyl alkynes. Influence of the alkene on the regioselectivity.
    Author: Aiguabella N, Arce EM, Del Pozo C, Verdaguer X, Riera A.
    Journal: Molecules; 2014 Feb 03; 19(2):1763-74. PubMed ID: 24496269.
    Abstract:
    The scope of the Pauson-Khand reaction (PKR) of internal trifluoromethyl alkynes, previously described with norbornadiene, is expanded to norbornene and ethylene. A thorough structural analysis of the resulting PK adducts has been carried out to unveil that α-trifluoromethylcyclopentenones are preferred in all cases, independently of the electronic properties of the alkyne. The regioselectivity observed with norbornadiene and ethylene is higher than in the case of norbornene.
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