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  • Title: [Anomalies of cellular immunity in Graves' disease treated by synthetic antithyroid drugs: effects on prognosis].
    Author: Allannic H, Genetet N, Edan G, Merdrignac G, Simon M, Genetet B.
    Journal: Pathol Biol (Paris); 1987 Dec; 35(10):1333-8. PubMed ID: 2449649.
    Abstract:
    The involvement of humoral immunity mechanism in etiology of Graves' disease was observed for the first time in 1956. Twenty years later cellular auto-immune dysfunction was also described. To day, there is evidence for suppressor T cell deficiency and decrease in T suppressor lymphocytes in Graves' disease and cell mediated immunity might be one of the most important point in the pathogenesis of Graves disease. For the future, cellular auto-immune dysfunction might be used to predict the evolution of the disease and to choice the best therapeutic scheme.
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