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  • Title: [Mitogenic action of substance P on the epithelial cells of the tongue].
    Author: Ivanov VM, Nadeev FI, Chelyshev IuA.
    Journal: Nauchnye Doki Vyss Shkoly Biol Nauki; 1987; (12):52-5. PubMed ID: 2449916.
    Abstract:
    Substance P (10 and 100 ng/ml) stimulates the proliferation of basal cells from rat's tongue epithelium in primary cultures with 2.5% fetal calf serum. In serum-free medium substance P have no effect on the epithelial cell growth. This neuropeptide secreted by afferent nerve fibers of the tongue epithelium is suggested to have a neurotrophic influence on epithelial cells controlling their proliferation.
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