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  • Title: Estimation of ochratoxin A in the human blood of Romanian population.
    Author: Zlăvog AV, Cuciureanu M, Schiriac E, Popa I, Diaconu C, Cuciureanu R.
    Journal: Rev Med Chir Soc Med Nat Iasi; 2013; 117(4):1009-13. PubMed ID: 24502083.
    Abstract:
    UNLABELLED: Ochratoxin A (OTA) is a toxic secondary metabolite of fungi belonging to the Aspergillus and Penicillium genera, its presence in human blood being the primary indicator of exposure. AIM: In the present study we determined OTA in 38 blood samples collected from healthy Romanian subjects of both genders. MATERIAL AND METHODS: The OTA was determined through the direct, competitive, solid-phase immunoenzymatic method; the minimum quantification limit for determining OTA in serum samples was 0.0289 ng/mL. RESULTS: The positive sample percentage was 100%. OTA concentrations varied between < 0.04 ng/mL and 1 ng/mL. There were no significant differences between OTA concentrations in men versus women (0.24 +/- 0.20 ng/mL versus 0.17 +/- 0.15 ng/mL, p = 0.3527). CONCLUSIONS: The analyzed blood samples exhibit a very high degree of exposure to OTA, but in only approximately 10% of the subjects exceeded 0.5 ng/mL, considered the threshold for OTA-induced renal pathology.
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