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  • Title: Separation of current- and voltage-dependent inactivation of calcium current in frog sensory neuron.
    Author: Akaike N, Tsuda Y, Oyama Y.
    Journal: Neurosci Lett; 1988 Jan 11; 84(1):46-50. PubMed ID: 2450318.
    Abstract:
    The inactivation process of the calcium current was studied in frog dorsal root ganglion cells using a newly developed 'concentration clamp' technique, and an inactivation component independent of Ca influx was separated from the Ca-dependent component. The neuron was first placed in Ca-free solution, and pre-pulses of various amplitude were applied, thereby inducing depolarization without the Ca influx. Successive test pulses were applied immediately after a rapid exchange to a solution containing normal Ca. The amount of inactivation under this condition was much smaller than that measured when both pre- and test pulses were applied in the normal solution, and reached a steady level on pre-pulses over +50 mV. We suggest that the inactivation process of the Ca current consists of two components, i.e. a dominant component which is dependent on Ca influx, and a smaller one which is presumably voltage-dependent.
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