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  • Title: Serum levels of anti-SRP54 antibodies reflect disease activity of necrotizing myopathy in a child treated effectively with combinatorial methylprednisolone pulses and plasma exchanges followed by intravenous cyclophosphamide.
    Author: Momomura M, Miyamae T, Nozawa T, Kikuchi M, Kizawa T, Imagawa T, Drouot L, Jouen F, Boyer O, Yokota S.
    Journal: Mod Rheumatol; 2014 May; 24(3):529-31. PubMed ID: 24506571.
    Abstract:
    We describe the effectiveness of combinatorial therapy with plasma exchanges and methylprednisolone pulses followed by intravenous cyclophosphamide in a young girl with anti-signal recognition particle 54 (SRP54) antibody-associated myopathy. We also use a newly described quantitative assay to demonstrate the close association between the titers of anti-SRP54 antibodies and disease activity. This is the first report of a pediatric patient indicating that the serum levels of anti-SRP54 antibodies are also beneficial for monitoring the disease activity of progressive necrotizing myopathy.
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