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  • Title: In vivo investigation of calcium phosphate coatings on Ti6-Al-4V alloy substrates using lactic acid - sodium lactate buffered synthetic body fluid.
    Author: Havitçioğlu H, Ceçen B, Pasinli A, Yüksel M, Aydin I, Yildiz H.
    Journal: Acta Orthop Traumatol Turc; 2013; 47(6):417-22. PubMed ID: 24509222.
    Abstract:
    OBJECTIVE: The aim of this study was to evaluate the mode of failure and biomechanical characteristics of Ti-6Al-4V anchors biomimetically coated with calcium phosphate (CaP) for soft tissue fixation to bone in an animal model. METHODS: The current study included 14 adult New Zealand white rabbits equally divided into two groups. Calcium phosphate-coated Ti-6Al-4V anchors were used in the test group and non-coated Ti-6Al-4V anchors in the control group. A new approach was applied to synthesize the CaP coatings via the biomimetic growth in the Lac-SBF containing Ca(2+) and PO4(3-) ions, Na-lactate and lactic acid (HL). Titanium anchors were implanted into the right tibia, followed by biomechanical tensile strength tests. Histological studies were carried out after removal of anchors (bone-implant surface). RESULTS: The CaP-coated Ti-6Al-4V anchors had significantly higher tensile strength (p=0.003) and displacement values (p=0.004) than the non-coated anchors. Control group scores were higher than those of the test group (14 and 9, respectively) in tensile strength tests. CONCLUSION: The new CaP coating can be used in orthopedic surgery as catalyzer to improve bone ingrowth. We believe that our research will form a model for further research on biomimetic coatings on Ti-6Al-4V substrates.
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