These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Calcium and secretagogues-induced conductances in rat exocrine pancreas.
    Author: Randriamampita C, Chanson M, Trautmann A.
    Journal: Pflugers Arch; 1988 Jan; 411(1):53-7. PubMed ID: 2451213.
    Abstract:
    The electrical properties of single acinar cells isolated from rat pancreas were studied with the whole-cell tight-seal recording method. Under resting conditions, the relative permeabilities of Cl and K were PCl/PK approximately equal to 3. At 1 microM internal calcium, a Ca and voltage-dependent Cl conductance was activated. At 10 microM internal calcium, the major conductance was selective for cations. It was not voltage-dependent. Acetylcholine and cholecystokinin induced an increase of internal Ca which in turn activated either only a Cl conductance or both Cl and cationic conductances. The secretagogue-induced conductance was increased to a variable extent by depolarisation. The absence of K channels activated by internal calcium indicates that, in pancreatic acinar cells, the mechanism of fluid secretion differs from that observed in other exocrine glands.
    [Abstract] [Full Text] [Related] [New Search]