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  • Title: [Chemical structure and immunostimulating activity of high molecular weight polysaccharides].
    Author: Sinilova NG, Duplishcheva AP, Romashevskaia EI, Mysiakin EB, Tumanian MA.
    Journal: Vopr Med Khim; 1987; 33(6):103-7. PubMed ID: 2451350.
    Abstract:
    An immunostimulating activity of high molecular polysaccharides, dissimilar in their chemical structure, was studied. Inoculation of mice with bacteria of typhoid fever and Kl. pneumoniae demonstrated that O-polysaccharide from typhoid bacteria--multicomponent, branch-chained, phosphorus-containing polysaccharide--exhibited the highest immunostimulating effect. Mannans and glucans, with linear and branch-chained molecules, involving various types of C-C bonds, had lower stimulating properties, which did not correlate with the level of a molecule branching and the type of C-C bonds. These data were confirmed after evaluation of adjuvant properties of high molecular polysaccharides with sheep erythrocytes and their ability to activate macrophages.
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