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  • Title: [Role of the hypophysis and hypothalamus in the control of feedback of the hypophyseal-adrenocortical system].
    Author: Filaretov AA, Balashov IuG, Iarushkina NI, Podvigina TT.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1988 Jan; 74(1):124-9. PubMed ID: 2451620.
    Abstract:
    The role of hypophysis and paraventricular hypothalamic nucleus in inhibition of pituitary-adrenocortical system induced with hydrocortisone in increasing doses (100, 300, 1200 mg/100 g b. w.) was studied in rats. The ACTH secretion induced with pituitrin was only decreased after administration of 1200 mg/100 g b. w. of hydrocortisone, whereas smaller doses did not alter the responsiveness of hypophysis. After lesion of the paraventricular hypothalamic nucleus the inhibition of the stress-induced reaction of pituitary-adrenocortical system was either eliminated or decreased depending on the dose of hydrocortisone administered. The inhibition induced with hydrocortisone in physiological doses seems to depend on the hypothalamus. However, both the hypothalamus and the hypophysis take part in an inhibition induced with supraphysiological doses of the hormone.
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