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  • Title: Monoclonal antibodies to the main immunogenic region of the nicotinic acetylcholine receptor bind to residues 61-76 of the alpha subunit.
    Author: Barkas T, Gabriel JM, Mauron A, Hughes GJ, Roth B, Alliod C, Tzartos SJ, Ballivet M.
    Journal: J Biol Chem; 1988 Apr 25; 263(12):5916-20. PubMed ID: 2451673.
    Abstract:
    Monoclonal antibodies (mAbs) to the main immunogenic region (MIR) bind to fusion proteins containing region 37-200 of the alpha chain of Torpedo, mouse, and chicken nicotinic acetylcholine receptor. In the case of the mouse alpha chain, these mAbs react with sequence 61-216 but not with 74-216. A synthetic peptide M1, containing residues 61-76 of the mouse alpha chain, also binds these anti-MIR mAbs, showing that all or part of their binding site is included in this region. The conformational dependence and epitope specificity of the mAbs are discussed.
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