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  • Title: Copper-promoted reductive homocoupling of quasi-aromatic iron(II) clathrochelates: boosting the inhibitory activity in a transcription assay.
    Author: Varzatskii OA, Novikov VV, Shulga SV, Belov AS, Vologzhanina AV, Negrutska VV, Dubey IY, Bubnov YN, Voloshin YZ.
    Journal: Chem Commun (Camb); 2014 Mar 25; 50(24):3166-8. PubMed ID: 24516860.
    Abstract:
    A copper-promoted reductive homocoupling reaction, for the first time used for a metal complex, allowed obtaining a new kind of complexes with the encapsulated metal ions, C-C conjugated bis-clathrochelates. These compounds demonstrate extremely high transcription inhibition activity in the T7 RNA polymerase system with values of IC50 reaching as low as the submicromolar range, which places them among the most potent metal-based transcription inhibitors.
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