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  • Title: Effects on brain cholecystokinin-8-sulfate and serotonin in adult rats after neonatal reduction of catecholamines.
    Author: Yamamoto H, Kato T.
    Journal: Neurosci Res; 1988 Feb; 5(3):265-71. PubMed ID: 2451793.
    Abstract:
    Depletion of dopamine (DA) in neonatal rats by cerebroventricular infusion of 6-hydroxydopamine with desmethylimipramine resulted in a significant decrease in mesolimbic immunoreactive cholecystokinin-8-sulfate (CCK-8SI) and a marked increase in striatal serotonin in 10-week-old rats. In contrast, neonatal norepinephrine (NE) depletion did not affect either CCK-8SI or serotonin in the frontal cortex, anterior cingulate cortex or hippocampus. Neonatal DA and NE depletion did not induce an increase in striatal serotonin.
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