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  • Title: The IP3 receptor as a hub for Bcl-2 family proteins in cell death control and beyond.
    Author: Parys JB.
    Journal: Sci Signal; 2014 Feb 11; 7(312):pe4. PubMed ID: 24518292.
    Abstract:
    Bcl-2 family proteins generally have a proapoptotic or antiapoptotic role. In addition to their known roles at the mitochondria, Bcl-2 family proteins also influence signaling at the endoplasmic reticulum by binding to the inositol 1,4,5-trisphosphate receptor (IP3R), the most ubiquitous intracellular Ca(2+) channel. Surprisingly, multiple Bcl-2 family proteins target different sites on the IP3R to elicit various effects on IP3R function, which suggests that the IP3R is an important hub for Bcl-2 family proteins in various physiological settings.
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