These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Cellular immune response to myelin basic proteins in patients with dilated cardiomyopathy].
    Author: Aleksandrova LZ, Bakhov NI, Titov VN, Gervazieva VB, Naumov VG.
    Journal: Ter Arkh; 1987; 59(12):51-7. PubMed ID: 2451862.
    Abstract:
    Peripheral blood lymphocytes (PBL) of patients with dilatation cardiomyopathy (DCMP), CHD and healthy persons were investigated for the presence of sensitization to the protein basic myelin (PB) for characterization of an immunopathological process in DCMP. In half of the DCMP patients there was sensitization to MMP, the presence of cytotoxic MMP-specific lymphocytes, a decrease in PBL suppressor and proliferative activity, an increase in IgG and IgM biosynthesis and lack of the lymphocytic capacity for induction of specific suppressor activity to this protein. A conclusion of myelin damage in DCMP development was made on the basis of the data obtained. An assumption was made of the appearance of focal inflammatory demyelinization in the myocardium accompanied by an autoimmune process with disorder of cooperative links of T- and B-lymphocytes.
    [Abstract] [Full Text] [Related] [New Search]