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  • Title: [Effect of 5-azacytidine on the frequency of polycentric chromosomes in cells with micronuclei during exposure to 5-bromodeoxyuridine].
    Author: Stobetskiĭ VI, Mironova LL.
    Journal: Biull Eksp Biol Med; 1988 Apr; 105(4):479-80. PubMed ID: 2451947.
    Abstract:
    Telomeric fusion of metaphase chromosomes was studied in conditions of DNA hypomethylation induced with 5-azacytidine. It was shown that the increased number of dicentric chromosomes was statistically significant in experiments when 5-azacytidine was used together with colcemid and 5-bromodeoxyuridine. These data demonstrate that DNA hypomethylation plays an important role in the manifestation of this phenomenon.
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