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  • Title: Dextromethorphan and dextrorphan as calcium channel antagonists.
    Author: Carpenter CL, Marks SS, Watson DL, Greenberg DA.
    Journal: Brain Res; 1988 Jan 26; 439(1-2):372-5. PubMed ID: 2451974.
    Abstract:
    Dextromethorphan and dextrorphan, which reduce excitatory amino acid-induced neurotoxicity, decreased K+ depolarization-evoked 45Ca2+ uptake into brain synaptosomes and cultured neural (PC12) cells. Half-maximal inhibition of synaptosomal 45Ca2+ uptake occurred with 48 microM dextromethorphan or 200 microM dextrorphan, which are similar to concentrations associated with protection from excitotoxicity. The ability to decrease Ca2+ flux through N-type (synaptosomal) and L-type (PC12) voltage-gated Ca2+ channels may therefore contribute to the neuroprotective effects of these compounds.
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