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  • Title: Synergistic cytotoxicity of recombinant human TNF and various anti-cancer drugs.
    Author: Watanabe N, Niitsu Y, Yamauchi N, Ohtsuka Y, Sone H, Neda H, Maeda M, Urushizaki I.
    Journal: Immunopharmacol Immunotoxicol; 1988; 10(1):117-27. PubMed ID: 2452179.
    Abstract:
    A synergistic increase in the cytotoxic effects of recombinant human tumor necrosis factor (rH-TNF) and anti-cancer drugs was demonstrated in vitro. The cytotoxicity of rH-TNF against L-M cells in combination with Mitomycin C (MMC), Adriamycin (ADM), Cytosine arabinoside (Ara-C), Actinomycin D (ACD), Daunomycin (DM), Cisplatin (CDDP), Vincristine (VCR), and 5-Fluorouracil (5FU), based on the concentration necessary for 50% inhibition of cell growth (IC50), was 4 to 347 times as high as that of rH-TNF alone. The results suggest that combination therapy including rH-TNF and anti-cancer drugs may be of value in the treatment of malignancy in human patients.
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