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  • Title: Galanin selectively modulates 5-hydroxytryptamine 1A receptors in the rat ventral limbic cortex.
    Author: Fuxe K, von Euler G, Agnati LF, Ogren SO.
    Journal: Neurosci Lett; 1988 Feb 15; 85(1):163-7. PubMed ID: 2452385.
    Abstract:
    The effects of galanin (10 nM) in vitro were analyzed on the binding characteristics of 5-hydroxytryptamine (5-HT) receptor subtypes in the ventral limbic cortex of the rat. It was found that galanin markedly decreased the Kd value of 5-HT1A binding, while there were no effects on the binding characteristics of the 5-HT1B or 5-HT2 radioligands. These results indicate that the existence of a selective intramembrane interaction between galanin receptors and 5-HT1A receptors in the rat ventral limbic cortex.
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