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  • Title: [ATP level in synaptosomes--a determining factor of the functional activity of ion channels induced by alpha-latrotoxin].
    Author: Pivneva TA, Gimmel'reĭkh NG, Nikolishina EV.
    Journal: Ukr Biokhim Zh (1978); 1988; 60(1):65-9. PubMed ID: 2452502.
    Abstract:
    The paper deals with characteristics of relationship between synaptosomal calcium permeability induced by alpha-latrotoxin and cytosolic concentration of ATP. It is shown that reagents decreasing the ATP level in the synaptosomes (monoiodoacetate, papaverine) inactivate the toxin-induced ionic fluxes and, on the contrary, reagents increasing the ATP level in synaptosomes enhance the toxin-induced calcium influx. The treatment of synaptosomes with inhibitors of phosphodiesterase of cAMP and cAMP-dependent protein kinase has no effect on the alpha-latrotoxin-induced calcium influx.
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