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  • Title: Polysaccharide based hydrogels as controlled drug delivery system for GIT cancer.
    Author: Singh B, Bala R.
    Journal: Int J Biol Macromol; 2014 Apr; 65():524-33. PubMed ID: 24530332.
    Abstract:
    Keeping in view the anticancer nature of psyllium and methotrexate, psyllium, if suitably tailored to prepare the hydrogels, can act as the potential candidate for the slow drug delivery systems for GI tract. Therefore, the present study is an attempt to modify the psyllium for developing the hydrogels meant for delivery of methotrexate in controlled and sustained manner. The present article discusses the synthesis and characterization of the psy-cl-poly(AAm-co-AAc) hydrogels prepared by chemical crosslinking methods. These hydrogels have been characterized with SEMs, FTIR, TGA, XRD and swelling studies. The swelling and drug release behavior of hydrogels has been determined in solution of different pH. The results indicate that the drug release from the polymeric matrix follows Fickian diffusion mechanism in pH 7.4 buffer.
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