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  • Title: Three new clerodane diterpenes from Polyalthia longifolia var. pendula.
    Author: Wu TH, Cheng YY, Chen CJ, Ng LT, Chou LC, Huang LJ, Chen YH, Kuo SC, El-Shazly M, Wu YC, Chang FR, Liaw CC.
    Journal: Molecules; 2014 Feb 13; 19(2):2049-60. PubMed ID: 24531220.
    Abstract:
    Three new clerodane diterpenes, (4→2)-abeo-cleroda-2,13E-dien-2,14-dioic acid (1), (4→2)-abeo-2,13-diformyl-cleroda-2,13E-dien-14-oic acid (2), and 16(R&S)- methoxycleroda-4(18),13-dien-15,16-olide (3), were isolated from the unripe fruit of Polyalthia longifolia var. pendula (Annonaceae) together with five known compounds (4-8). The structures of all isolates were determined by spectroscopic analysis. The anti-inflammatory activity of the isolates was evaluated by testing their inhibitory effect on NO production in LPS-stimulated RAW 264.7 macrophages. Among the isolated compounds, 16-hydroxycleroda-3,13-dien-15,16-olide (6) and 16-oxocleroda-3,13-dien-15-oic acid (7) showed promising NO inhibitory activity at 10 µg/mL, with 81.1% and 86.3%, inhibition, respectively.
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